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When a burned patient seeks your help, and you drip or spray heparin solution on the painful raw burn surface, the pain will be relieved within a few minutes, and the angry redness will blanche. Then, when you insert heparin solution into painful blisters and rinse the blister with the heparin solution, the blister pain will be relieved in less than a minute. The burn surface and blisters will not be as warm. You and your patient will recognize that you have initiated prompt effective therapy. You will not need to administer any ‘pain medicine’. Heparin stopped pain and initiated burn therapy. In fact 3 of the 4 four signs of inflammation (pain, redness, and heat) will be gone.

If and when, after a variable period of time, the patient’s burn surface pain returns in a lesser amount, retreatment by topical application of Heparin will again relieve the pain. With continued use of heparin, the 4th sign of inflammation, namely swelling, that is common to burns not treated with heparin will be reduced or absent, because Heparin stops burn inflammation. With less swelling, there will be little or no need for fasciotomies.

For patients who additionally have a vague deeper pain, intravenous infusion of Heparin solution rapidly relieves the pain and blanches the erythema, if it is present. Subcutaneous deposit of heparin solution into fat more slowly relieves the pain and blanches erythema.

No pain medicine will be needed. Unlike burned patients who receive sedating pain medicine, like morphine, Heparin-treated patients are comfortable, alert, and do not suffer from a depression of respirations or intestinal movements. Patients have less or no swelling. They are able to eat and drink, be more physically active, and even to assist with their treatment. (See Protocol Link for details of Method. See Case Studies pictures to see patients’ condition.)

ALL OTHER TREATMENT METHODS ARE COMPATIBLE WITH INITIAL USE OF HEPARIN. DOCTORS CAN INITIALLY SEE BURNED PATIENTS AND LATER, IF NECESSARY, REFER THEM TO BURN SPECIALISTS. Plastic surgeons can then undertake plastic surgery if and when necessary, which is the most efficient use of their time and talents, as they are not burdened with the early burn care.

Adding Heparin improves treatment, reduces procedures, and makes cost affordable and sustainable. Use of heparin first reduces and avoids the loss of blood that commonly occurs when surgery is used to debride the wound and place skin substitute or grafts. With little or no loss of blood, there is little or no need for blood transfusions, and no danger of transmitting disease through blood. With early first use of heparin, the burn site is ideally prepared with richly vascular granulation tissue for successful skin-grafting, should it be needed. With continued use of Heparin topically into healing, the cosmetic skin results are vastly imporoved, usually void of scars and contractures. (See Science of Heparin Use.)

Adding heparin to burn treatment has made treatment of burns affordable worldwide.


Heparin is precise therapy for the concise pathology of burns. The known sequential multiple burn-pathology stages and the sequential known multiple heparin properties-and-effects healing stages are a perfect therapeutic match. Similarly heparin is a therapeutic match for the pathology stages of chronic wounds and difficult to treat chronic skin problems. Burn Pathology Phases involve:
(1) sluggish blood flow with coagulation, infarctions, emboli, and DIC;
(2) cascading tissue-destructive inflammation;
(3) ischemia and gangrene;
(4) delayed and deficient granulation
(5) inadequate replacement of collagen and smooth muscle and skin tissue-cells, and
(6) disrupted epithelialization with scars and contractures.

Heparin’s matching Therapeutic Effects are
(1) anticoagulating;
(2) anti-inflammatory;
(3) neoangiogenic-revascularizing
(4) collagen restoring-regulating,
(5) smooth muscle cell and dermal cell stimulating-regulating; and
(5) epithelializing with dermal cells that results in smooth skin consistently void of scars or contractures. Heparin effects and properties therapeutically stops, reverses, corrects, favorably alters, stimulates, replaces, regulates, and heals the corresponding matching burn pathology phases.

Heparin use first, when not contraindicated, is compatible with other therapy methods, including surgery - slightly delayed, in less quantity, under more favorable conditions.

Heparin produces richly-vascular granulation tissue ideal for successful skin grafting or skin cell implant with the patients own cultured skin cells. The initial nearly total surgical resection of the burn under anesthesia via intubation, with blood loss and transfusions is not necessary. Using heparin first, the patients are not toxic, mortality is not increased – it is decreased, blood loss and transfusions are eliminated, much medical healing of burns is achieved, and the need to cover the denuded area with skin grafts or artificial membranes is often avoided.

Healing is complete in many patients with use of heparin alone, especially in children. Patients requiring surgery or in cases where surgery is desirable can still have surgery by stopping heparin for 1 to 2 days, or rarely 3 days until Blood Clotting Times return to the normal range.

Heparin is ideal for use in one burned person or the many burned in Thermal Disasters. In a thermal disaster, heparin sprayed on burns and in blisters would cost-effectively promptly relieve pain, stop inflammation, and initiate affordable therapy as a first-response workable treatment, where no cost-effective therapy is now available.