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1. Saliba MJ Jr. Heparin in the treatment of burns: a review. BURNS, J International

Society for Burn Injuries. 2001;27:349-358.

2.Reyes A, Astiazaran JA, Chavez CC, Jaramillo F and Saliba MJ. Burns treated with and

without heparin: controlled use in a thermal disaster. Annals of Burns and Fire Disasters.


3. Glucosaminoglycans In Burns: Multi-Center Update: Proceedings: 10th CONGRESS OF


Abstracts of presentations: Saliba, MJ Jr., La Jolla, CA USA. p 10,11,20,34,70; Mangus DJ.

Chico, CA USA. p 20; Ramakrishnan KM., Madras, INDIA. p 11,11, 21; Traber DL.,

Galveston, TX, USA p 11,34; Dmitreinko, O., St. Petersburg, RUSSIA p 11; Hruba, J.

Prague, Czech Republic p 10. Hansbrough JF. San Diego, CA USA p 10.


INTERNATIONAL MEETING. Feb 24-27 1994. San Diego, CA, USA. Editor: Dr Saliba. Saliba

MJ Jr, p3-8,15-68; Green BE, p9-14; Ramakrishnan KM, p69-73,84-93,123-126; Cox CS,

p74-82; Hansbrough JF, Abst p28; Traber L, p94-122; Mangus DJ, p127+19p; Konigova

R, and Hubra J, p128-131. Reprints: Tel/Fax:USA + 858 454 2686 or write: Michael J.

Saliba Jr., MD. 5582 Thunderbird Lane, La Jolla, CA 92037 USA

5. Rigdon RH, and Wilson H. Capillary permeability and inflammation in rabbits given

heparin. Arch Surg. 1941;43:64-73.

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heparin on local pathology of burns Surgery. 1949;26:548-564.

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12. Brooks F, Dragstedt LR, Warner L, and Knisely MH. Sludged blood following severe

themal burns. Arch Surg. 1950;61:387-418.

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14. Keller R. Zor bindung von histamin und serotonin in den mastzellen. Arzneimittel-

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serotonin on vascular permeability. J Biophys & Biochem Cytol. 1961;11:571-605.

16. Kobayasch Y. Histamin binding by heparin. Biochem & Biophy. 1962;96:20-27.

17. Dolowitz DA, and Dougherty TF. The use of heparin as an antiinflammatory agent.

Laryngoscope. 1960;70:873-.

18. Doughtery TF, and Dolowitz DA. Physiologic actions of heparin not related to blood

clotting. Am J Cardiology. 1964;14:18-.

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mesentery venules. Am J Physiol. 1991;260;H1667-H1673.

21. Saliba MJ Jr. Heparin in the treatment of burns. JAMA. 1967;200:650.

22. Saliba MJ Jr. Heparin efficacy in burns. II. Human thermal burn treatment with large

doses of topical and parenteral heparin. Aerospace Medicine. 1970;41:1302-1312.

23. Saliba MJ Jr, Dempsey WC, and Kruggel JL. Large burns in humans, treatment with

heparin. JAMA. 1973;225:261-269.

24. Saliba MJ Jr. Heparin, nature's own burn remedy? Emergency Medicine.


25. Saliba MJ Jr and Saliba RJ. Heparin in burns: dose related and dose dependent effects.

Thrombos Diasthes Haemorrh (Stuttig). 1974;33:113-.

26. Saliba MJ Jr: The effects and uses of heparin in the care of burns that improves

treatment and enhances the quality of life. Acta Chirurgiae Plasticae 1997;39:13-16.

27. Saliba MJ Jr, Covell JM, Bloor CM. Effects of heparin in large doses on the extent of

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myocardial ischemia after acute coronary occlusion in the dog. Am J Cardiol. 1976;37:599-


28. Saliba, MJ Jr, Kuzman WJ, and Miller M. Effect of heparin in anticoagulant doses on the

ECG and cardiac enzymes in patients with acute myocardial infarction. Am J Cardiol.


29. Saliba MJ Jr, and Griner L.A: Heparin efficacy in burns. I. Significant early modification

of experimental third-degree guinea pig thermal burn. Aerospace Med. 1970;41:179-.

30. Chemical mediators of inflammation. In: Cotran RS, Robbins SL, and Kumar V, eds

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Diego, CA USA 1994;p 69-73. Dr Saliba, Editor Tel/Fax+ 858 454 2686.

45. Ramarkrishnan KM, and Jayaraman V. Heparin effects in burn pathophysiology. In:

Proceedings. See Ref 46. 1994;p123-126. Dr Saliba, Editor Tel/Fax: 858 454 2686

46. Ramakrishnan KM, and Jayaraman V. Beneficial effects of topical heparin in burn

wound healing. In: Proceedings. Ref 2. 1994;p84-93. And Ref 1. 1998;p11.

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burned humans using heparin administered parenterally. In Proceedings. Ref 2 1994;p87-

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synthesis in burns treated with both systemic and local heparin use that improved burn

care. In Proceedings. Ref 2 1994;p124-129. And Ref 1 1998;p21. Contact: K. Mathangi

Ramakrishnan, MB. FRCS. M.Ch. D.Sc., Director, Pediatric Burn ICU & Plastic Surg Chief,

Childs Trust Hospital, Madras India. Fax: + 91 44 823 4044.

50. Dmitrienko O., Bagnenko S., Kuzulin D., Ankin Tu., Takimov D. Experiences with

heparin care in burned patients: with topical and parenteral use. St Petersburg Russia.

10th ISBI (See Ref 1.) 1998:p11. Contact: Dr Dmitrienko Tel/Fax: + 7 812 314 2233.

51. Saliba MJ, Bonilla A, and Zayas C. Initial heparin use topically and parenterally in

burned children in El Salvador. 1999: Preprint.

52. Bonilla A, Saravia M, Zayas C, and Saliba M. Heparin effects by parenteral, topical,

and inhalation in human burns in El Salvador. 1999: Preprint.

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54. Macaig T et al. Heparin binds endothelial cell growth factor, the principal endothelial

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55. Folkman J. Weisz PB, Joullie MM, Li WW, Ewing WR. Control of angiogenesis with

synthetic heparin substitutes. Science 1989;243:1490-1493.

56. Zapata-Sirvant RL, Hansbrough JF, Greenleaf GE, et al. Reduction of bacterial

translocation and intestinal structure alterations by heparin in a murine burn injury model.

The Journal of Trauma. 1994;36:1-6. And in Ref 1 and 2 of this review.

57. Gianotti L, Alexander JW, Fukushima R, Pyles T. Reduction of bacterial translocation

with oral fibroblast growth factor and sucralfate. Am J Surg. 1993;165:195-200.

58. Hruba J. Prevention of stress bleeding in burn medicine. Using heparin and sucralfate.

In Proceedings Ref 2. 1994:p127-131. And in Ref 1.

59. Ferrao AV and Mason RM: The effect of heparin on cell proliferation and type-I

collagen synthesis by adult human dermal fibroblasts. Biochemica et Biophysica Acta


60. McCarthy DW; Downing MT; Brigstock DR; Luquette MH; Brown KD; Abad MS; Gesner

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62. Cox CS, Zwischenberger JB, Traber DL, et al. Heparin improves oxygenation and

minimizes barotrauma after severe smoke inhalation in ovine model. Surg Gynecol Obstet.


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64. Desai MH MD, Mlcak RRT RCP, Richardson RCP RRT, et al. Reduction in mortality in

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